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施蕴渝

物电学院   15-05-06 10:12:32 作者:SystemMaster 来源:未知 文字大小:[] [] []

  

教授,中国科学院院士,发展中国家科学院院士
学历:1965年本科毕业于中国科学技术大学物理系生物物理专业。
主要工作经历:1965年-1970年卫生部中医研究院实习研究员,1970年至今在中国科技大学任助教,讲师,副教授,教授,期间曾分别在意大利罗马大学及CNRS结构化学研究所、荷兰格罗宁根大学、法国CNRS结构生物学实验室,理论化学实验室进修或互助研究。
国内外学术兼职:国际磁共振学会理事会成员;Current Opinion in Structural Biology,Editorial Board member;Biochemistry,Editorial Advisory Board member;Faculty F1000,Editorial Advisory Board member; Science in China,Life Sciences,Editorial Board member;中国生物物理学会常务理事;中国生物物理学会-生物磁共振专业委员会理事长;中国生化与分子生物学学会蛋白质专业委员会副主任。


研究兴趣
基因表达调控,特别是表观遗传调控,包括组蛋白修饰,染色体重塑料,非编码RNA调控,以及细胞粘附与转移的分子机理。上述过程与生物体发育和细胞分化以及各种疾病的产生和发展密切相关。我们从结构生物学角度重点研究上述过程中蛋白质结构,动力学与功能的关系,以及蛋白质与蛋白质,蛋白质与核酸,蛋白质与小分子配基的相互作用。


主要在研课题:
国家自然科学基金委重点项目;国家自然科学基金委面上课题;中国科学院先导B类课题


主要代表论文:
1. Wang L, Wang W, Li F, Zhang J, Wu J, Gong Q*, Shi Y*. Structural insights into the recognition of the internal A-rich linker from OxyS sRNA by Escherichia coli Hfq.Nucleic Acids Res. 2015, 43(4):2400-11.
2. Liu Z, Li F, Zhang B, Li S, Wu J*, Shi Y*. Structural Basis of Plant Homeodomain Finger 6 (PHF6) Recognition by Retinoblastoma Binding Protein 4 (RBBP4) Component of the Nucleosome Remodeling and Deacetylase (NuRD) Complex. J Biol Chem. 2015, 290(10):6630-8
3. Li F, Zhao D, Wu J*, Shi Y*. Structure of the YTH domain of human YTHDF2 in complex with an m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition. , Cell Res. 2014, 24(12):1490-2.
4. Wang C, Zhu Y, Caceres TB, Liu L, Peng J, Wang J, Chen J, Chen X, Zhang Z, Zuo X, Gong Q, Teng M, Hevel JM, Wu J*, Shi Y*. Structural Determinants for the Strict Monomethylation Activity by Trypanosoma brucei Protein Arginine Methyltransferase 7, Structure. 2014, 22(5):756-68.
5. Wang J, Qin S, Li F, Li S, Zhang W, Peng J, Zhang Z, Gong Q, Wu J*, Shi Y*. Crystal structure of human BS69 Bromo-ZnF-PWWP reveals its role in H3K36me3 nucleosomes binding. Cell Res. 2014, 24, 890-3.
6. Liu Z, Li F, Ruan K, Zhang J, Mei Y, Wu J*, Shi Y*, Structural and functional insights into the human B?rjeson-Forssman-Lehmann syndrome-associated protein PHF6. J Biol Chem. 2014, 289(14):10069-83
7. Wang C, Zhu Y, Chen J, Li X, Peng J, Chen J, Zou Y, Zhang Z, Jin H, Yang P, Wu J, Niu L, Gong Q, Teng M*, Shi Y*. Crystal structure of arginine methyltransferase 6 from Trypanosoma brucei. PLoS One. 2014,9(2):e87267.
8. Chao He, Sreerekha S. Pillai, Francesca Taglini, Fudong Li, Ke Ruan, Jiahai Zhang, Jihui Wu, Yunyu Shi*, and Elizabeth H. Bayneb*, Structural analysis of Stc1 provides insights into the coupling of RNAi and chromatin modification, Proc Natl Acad Sci U S A. 2013,110(21):E1879-88.
9. He Chao, Li Fudong, Zhang Jiahai, Wu Jihui*, Shi Yunyu*. The Methyltransferase NSD3 Has Chromatin-binding Motifs, PHD5-C5HCH, That Are Distinct from Other NSD (Nuclear Receptor SET Domain) Family Members in Their Histone H3 Recognition. J Biol Chem , 2013, 288(7):4692-703.
10. Deshun Gong, Fan Yang, Fudong Li,  Dandan Qian, Minhao Wu, Zhenhua Shao,  Mian Wu,  Jihui Wu*, and Yunyu Shi*. Crystal structure and functional characterization of the human RBM25 PWI domain and its flanking basic region. Biochem J. 2013, 450(Pt 1): 85–94.
11. Sai Li, M. P. Wandel, Fudong Li, Zhonghua Liu, Chao He, Jihui Wu, Yunyu Shi*, F. Randow*.Sterical Hindrance Promotes Selectivity of the Autophagy Cargo Receptor NDP52 for the Danger Receptor Galectin-8 in Antibacterial Autophagy.  Science Signal. 2013, 6, ra9.
12.Yu Qiu, Lei Liu, Chen Zhao, Chuanchun Han, Fudong Li, Jiahai Zhang, Yan Wang, Guohong Li, Yide Mei, Mian Wu, Jihui Wu* and Yunyu Shi* . Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription.Genes & Dev. 2012. 26: 1376-1391.
13. Xinxin Li, Kaixian Liu, Fudong Li, Juncheng Wang, Hongda Huang, Jihui Wu*,and Yunyu Shi* (2012)  Structure of the C-terminal tandem BRCT repeats of Rtt107 reveals a critical role in the interaction with γH2A during DNA damage repair . The Journal of Biological Chemistry, 2012, 287, 9137-9146. 
14. Weiwei Wang, Lijun Wang, Yang Zou, Jiahai Zhang, Qingguo Gong, Jihui Wu, Yunyu Shi* Cooperation of Escherichia coli Hfq hexamers in DsrA binding, Genes & Development. 2011, 25(19):2106-2117.
15. Jianping Liu, Jiahai Zhang, Qingguo Gong, Peng Xiong, Hongda Huang, Bo Wu, Guowei Lu, Jihui Wu* and Yunyu Shi*. Solution structure of the tandem SH2 domains from Spt6 and their binding to the phosphorylated RNA polymerase II C-terminal domain. Journal of Biological Chemistry, 2011, 286(33):29218-29226。


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